000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Consolidated Balance Sheets link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Consolidated Balance Sheets (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Consolidated Statements of Stockholders' Equity link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Consolidated Statements of Stockholders' Equity (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 006 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:definitionLink link:presentationLink 007 - Disclosure - Note 1 - Description of Business link:calculationLink link:definitionLink link:presentationLink 008 - Disclosure - Note 2 - Summary of Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 009 - Disclosure - Note 3 - Investments and Fair Value of Financial Instruments link:calculationLink link:definitionLink link:presentationLink 010 - Disclosure - Note 4 - Balance Sheet Components link:calculationLink link:definitionLink link:presentationLink 011 - Disclosure - Note 5 - Goodwill link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note 7 - Research Grants and Agreements link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note 8 - Controlled Launch link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note 9 - Revenue link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Note 10 - Segment Reporting link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note 11 - Income Taxes link:calculationLink link:definitionLink link:presentationLink 018 - Disclosure - Note 12 - Related Party Transactions link:calculationLink link:definitionLink link:presentationLink 019 - Disclosure - Note 13 - Commitments and Contingencies link:calculationLink link:definitionLink link:presentationLink 020 - Disclosure - Note 14 - Restructuring Charges link:calculationLink link:definitionLink link:presentationLink 021 - Disclosure - Note 15 - Employee Benefit Plans link:calculationLink link:definitionLink link:presentationLink 022 - Disclosure - Note 16 - Supplementary Financial Information link:calculationLink link:definitionLink link:presentationLink 023 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 024 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Tables) link:calculationLink link:definitionLink link:presentationLink 025 - Disclosure - Note 3 - Investments and Fair Value of Financial Instruments (Tables) link:calculationLink link:definitionLink link:presentationLink 026 - Disclosure - Note 4 - Balance Sheet Components (Tables) link:calculationLink link:definitionLink link:presentationLink 027 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation (Tables) link:calculationLink link:definitionLink link:presentationLink 028 - Disclosure - Note 10 - Segment Reporting (Tables) link:calculationLink link:definitionLink link:presentationLink 029 - Disclosure - Note 11 - Income Taxes (Tables) link:calculationLink link:definitionLink link:presentationLink 030 - Disclosure - Note 13 - Commitments and Contingencies (Tables) link:calculationLink link:definitionLink link:presentationLink 031 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 032 - Disclosure - Note 2 - Summary of Significant Accounting Policies - Warrant Accrual Activity (Details) link:calculationLink link:definitionLink link:presentationLink 033 - Disclosure - Note 2 - Summary of Significant Accounting Policies - Antidilutive Securities (Details) link:calculationLink link:definitionLink link:presentationLink 034 - Disclosure - Note 3 - Investments and Fair Value of Financial Instruments (Details Textual) link:calculationLink link:definitionLink link:presentationLink 035 - Disclosure - Note 3 - Investments and Fair Value of Financial Instruments - Financial Assets Measured on a Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 036 - Disclosure - Note 4 - Balance Sheet Components (Details Textual) link:calculationLink link:definitionLink link:presentationLink 037 - Disclosure - Note 4 - Balance Sheet Components - Inventory (Details) link:calculationLink link:definitionLink link:presentationLink 038 - Disclosure - Note 4 - Balance Sheet Components - Property and Equipment, Net (Details) link:calculationLink link:definitionLink link:presentationLink 039 - Disclosure - Note 4 - Balance Sheet Components - Intangible Assets, Net (Details) link:calculationLink link:definitionLink link:presentationLink 040 - Disclosure - Note 4 - Balance Sheet Components - Schedule of Amortization of Intangible Assets (Details) link:calculationLink link:definitionLink link:presentationLink 041 - Disclosure - Note 4 - Balance Sheet Components - Accrued Expenses (Details) link:calculationLink link:definitionLink link:presentationLink 042 - Disclosure - Note 5 - Goodwill (Details Textual) link:calculationLink link:definitionLink link:presentationLink 043 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 044 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Summary of Warrants Activity (Details) link:calculationLink link:definitionLink link:presentationLink 045 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Summary of Stock Option Activity (Details) link:calculationLink link:definitionLink link:presentationLink 046 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Summary of Time-based Option Activity (Details) link:calculationLink link:definitionLink link:presentationLink 047 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Summary of Performance Option Activity (Details) link:calculationLink link:definitionLink link:presentationLink 048 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Option Assumptions (Details) link:calculationLink link:definitionLink link:presentationLink 049 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - ESPP Assumptions (Details) link:calculationLink link:definitionLink link:presentationLink 050 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Stock-based Compensation Expense by Recorded Location (Details) link:calculationLink link:definitionLink link:presentationLink 051 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Stock-based Compensation Expense by Type (Details) link:calculationLink link:definitionLink link:presentationLink 052 - Disclosure - Note 7 - Research Grants and Agreements (Details Textual) link:calculationLink link:definitionLink link:presentationLink 053 - Disclosure - Note 8 - Controlled Launch (Details Textual) link:calculationLink link:definitionLink link:presentationLink 054 - Disclosure - Note 9 - Revenue (Details Textual) link:calculationLink link:definitionLink link:presentationLink 055 - Disclosure - Note 10 - Segment Reporting (Details Textual) link:calculationLink link:definitionLink link:presentationLink 056 - Disclosure - Note 10 - Segment Reporting - Revenue by Product (Details) link:calculationLink link:definitionLink link:presentationLink 057 - Disclosure - Note 10 - Segment Reporting - Revenue by Geography (Details) link:calculationLink link:definitionLink link:presentationLink 058 - Disclosure - Note 11 - Income Taxes (Details Textual) link:calculationLink link:definitionLink link:presentationLink 059 - Disclosure - Note 11 - Income Taxes - Income (Loss) Before Income Taxes (Details) link:calculationLink link:definitionLink link:presentationLink 060 - Disclosure - Note 11 - Income Taxes - Components of Provision for Income Taxes (Details) link:calculationLink link:definitionLink link:presentationLink 061 - Disclosure - Note 11 - Income Taxes - Reconciliation of Provision for Income Taxes (Details) link:calculationLink link:definitionLink link:presentationLink 062 - Disclosure - Note 11 - Income Taxes - Deferred Tax Asset (Liability) (Details) link:calculationLink link:definitionLink link:presentationLink 063 - Disclosure - Note 11 - Income Taxes - Reconciliation of Unrecognized Tax Benefit (Details) link:calculationLink link:definitionLink link:presentationLink 064 - Disclosure - Note 12 - Related Party Transactions (Details Textual) link:calculationLink link:definitionLink link:presentationLink 065 - Disclosure - Note 13 - Commitments and Contingencies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 066 - Disclosure - Note 13 - Commitments and Contingencies - Information Related to Right-of-use Assets and Lease Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 067 - Disclosure - Note 14 - Restructuring Charges (Details Textual) link:calculationLink link:definitionLink link:presentationLink 068 - Disclosure - Note 15 - Employee Benefit Plans (Details Textual) link:calculationLink link:definitionLink link:presentationLink