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  <xsd:element id="plse_IssuanceCostsIncurredInNoncashOrPartNoncashTransaction" name="IssuanceCostsIncurredInNoncashOrPartNoncashTransaction" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_LaboratoryEquipmentMember" name="LaboratoryEquipmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="plse_LesseeOperatingLeaseMonthlyRent" name="LesseeOperatingLeaseMonthlyRent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="plse_LesseeOperatingLeaseRentAnnualIncreasePercentage" name="LesseeOperatingLeaseRentAnnualIncreasePercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="plse_LetterAgreementMember" name="LetterAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_LoanAgreementMember" name="LoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_MajorityStockholderAndCochairmanMember" name="MajorityStockholderAndCochairmanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_MarketbasedOptionsMember" name="MarketbasedOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_MiamiLeaseMember" name="MiamiLeaseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_ModifiedMarketBasedAwardsMember" name="ModifiedMarketBasedAwardsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_ModifiedTimeBasedAwardsMember" name="ModifiedTimeBasedAwardsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="plse_NumberOfSharesPerUnitIssued" name="NumberOfSharesPerUnitIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant"/>
  <xsd:element id="plse_NumberOfWarrantsInEachUnit" name="NumberOfWarrantsInEachUnit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant"/>
  <xsd:element id="plse_NumberOfWarrantsPerUnit" name="NumberOfWarrantsPerUnit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant"/>
  <xsd:element id="plse_OperatingLossCarryforwardsNotSubjectToExpiration" name="OperatingLossCarryforwardsNotSubjectToExpiration" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="plse_OtherReceivableFromExerciseOfWarrants" name="OtherReceivableFromExerciseOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="plse_PatentCosts" name="PatentCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="plse_PatentCostsPolicyTextBlock" name="PatentCostsPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="plse_PercentOfOfferingPurchased" name="PercentOfOfferingPurchased" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_PerformanceOptionsMember" name="PerformanceOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_PerformancebasedAndMarketbasedOptionsMember" name="PerformancebasedAndMarketbasedOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_PerformancebasedOptionsMember" name="PerformancebasedOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="plse_ProceedsFromIssuanceOfCommonStockAndWarrants" name="ProceedsFromIssuanceOfCommonStockAndWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="plse_RightOfferingDeemedDividend" name="RightOfferingDeemedDividend" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_RightsOfferingMember" name="RightsOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_RightsOfferingWarrantsMember" name="RightsOfferingWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_RobertWDugganMember" name="RobertWDugganMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="plse_ScheduleOfInformationRelatedToRightofuseAssetsAndLeaseLiabilitiesTableTextBlock" name="ScheduleOfInformationRelatedToRightofuseAssetsAndLeaseLiabilitiesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="plse_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueOfSharesModified" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueOfSharesModified" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="plse_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesModified" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesModified" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="plse_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsGrantsInPeriodIntrinsicValue" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsGrantsInPeriodIntrinsicValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="plse_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsModificationsInPeriod" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsModificationsInPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="plse_SharebasedCompensationArrangementsBySharebasedPaymentAwardOptionsModificationsInPeriodWeightedAverageExercisePrice" name="SharebasedCompensationArrangementsBySharebasedPaymentAwardOptionsModificationsInPeriodWeightedAverageExercisePrice" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="duration"/>
  <xsd:element id="plse_StockIssuedDuringPeriodSharesExerciseOfWarrants" name="StockIssuedDuringPeriodSharesExerciseOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="plse_StockIssuedDuringPeriodValueExerciseOfWarrants" name="StockIssuedDuringPeriodValueExerciseOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="plse_SubscriptionRightNumberOfUnits" name="SubscriptionRightNumberOfUnits" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="plse_The2015Plan2017PlanAndInducementPlanMember" name="The2015Plan2017PlanAndInducementPlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_The2017EmployeeStockPurchasePlanMember" name="The2017EmployeeStockPurchasePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_The2017InducementEquityIncentivePlanMember" name="The2017InducementEquityIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_The2017PlanMember" name="The2017PlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_The2024RightOfferingMember" name="The2024RightOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_TimebasedAndPerformanceOptionsMember" name="TimebasedAndPerformanceOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_TimebasedOptionsMember" name="TimebasedOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_TwoThousandTwentyTowLoanAgreementMember" name="TwoThousandTwentyTowLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_VestingOfFirstHalfMember" name="VestingOfFirstHalfMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_VestingOfSecondHalfMember" name="VestingOfSecondHalfMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_WarrantsIssuedIn2024RightsOfferingMember" name="WarrantsIssuedIn2024RightsOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-2-summary-of-significant-accounting-policies-antidilutive-securities-details" name="statement-statement-note-2-summary-of-significant-accounting-policies-antidilutive-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-2-summary-of-significant-accounting-policies-tables" name="statement-statement-note-2-summary-of-significant-accounting-policies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-3-fair-value-of-financial-instruments-financial-assets-measured-on-a-recurring-basis-details" name="statement-statement-note-3-fair-value-of-financial-instruments-financial-assets-measured-on-a-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-3-fair-value-of-financial-instruments-tables" name="statement-statement-note-3-fair-value-of-financial-instruments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-4-balance-sheet-components-accrued-expenses-details" name="statement-statement-note-4-balance-sheet-components-accrued-expenses-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-4-balance-sheet-components-intangible-assets-net-details" name="statement-statement-note-4-balance-sheet-components-intangible-assets-net-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-4-balance-sheet-components-property-and-equipment-net-details" name="statement-statement-note-4-balance-sheet-components-property-and-equipment-net-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-4-balance-sheet-components-schedule-of-amortization-of-intangible-assets-details" name="statement-statement-note-4-balance-sheet-components-schedule-of-amortization-of-intangible-assets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-4-balance-sheet-components-tables" name="statement-statement-note-4-balance-sheet-components-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-6-stockholders-equity-and-stockbased-compensation-espp-assumptions-details" name="statement-statement-note-6-stockholders-equity-and-stockbased-compensation-espp-assumptions-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-6-stockholders-equity-and-stockbased-compensation-option-assumptions-details" name="statement-statement-note-6-stockholders-equity-and-stockbased-compensation-option-assumptions-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-6-stockholders-equity-and-stockbased-compensation-stockbased-compensation-expense-details" name="statement-statement-note-6-stockholders-equity-and-stockbased-compensation-stockbased-compensation-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-6-stockholders-equity-and-stockbased-compensation-summary-of-marketbased-option-activity-details" name="statement-statement-note-6-stockholders-equity-and-stockbased-compensation-summary-of-marketbased-option-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-6-stockholders-equity-and-stockbased-compensation-summary-of-performance-option-activity-details" name="statement-statement-note-6-stockholders-equity-and-stockbased-compensation-summary-of-performance-option-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-6-stockholders-equity-and-stockbased-compensation-summary-of-stock-option-activity-details" name="statement-statement-note-6-stockholders-equity-and-stockbased-compensation-summary-of-stock-option-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-6-stockholders-equity-and-stockbased-compensation-summary-of-timebased-option-activity-details" name="statement-statement-note-6-stockholders-equity-and-stockbased-compensation-summary-of-timebased-option-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-6-stockholders-equity-and-stockbased-compensation-summary-of-warrants-activity-details" name="statement-statement-note-6-stockholders-equity-and-stockbased-compensation-summary-of-warrants-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-6-stockholders-equity-and-stockbased-compensation-tables" name="statement-statement-note-6-stockholders-equity-and-stockbased-compensation-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-7-commitments-and-contingencies-information-related-to-rightofuse-assets-and-lease-liabilities-details" name="statement-statement-note-7-commitments-and-contingencies-information-related-to-rightofuse-assets-and-lease-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-7-commitments-and-contingencies-tables" name="statement-statement-note-7-commitments-and-contingencies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-8-income-taxes-deferred-tax-asset-liability-details" name="statement-statement-note-8-income-taxes-deferred-tax-asset-liability-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-8-income-taxes-income-loss-before-income-taxes-details" name="statement-statement-note-8-income-taxes-income-loss-before-income-taxes-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-8-income-taxes-reconciliation-of-provision-for-income-taxes-details" name="statement-statement-note-8-income-taxes-reconciliation-of-provision-for-income-taxes-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-8-income-taxes-reconciliation-of-unrecognized-tax-benefit-details" name="statement-statement-note-8-income-taxes-reconciliation-of-unrecognized-tax-benefit-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-8-income-taxes-tables" name="statement-statement-note-8-income-taxes-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-9-segment-reporting-reconciliation-of-net-loss-details" name="statement-statement-note-9-segment-reporting-reconciliation-of-net-loss-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-note-9-segment-reporting-tables" name="statement-statement-note-9-segment-reporting-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="plse_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
