000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Consolidated Balance Sheets link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Consolidated Balance Sheets (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Consolidated Statements of Stockholders' Equity (Deficit) link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Consolidated Statements of Stockholders' Equity (Deficit) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 006 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:definitionLink link:presentationLink 007 - Disclosure - Note 1 - Description of the Business link:calculationLink link:definitionLink link:presentationLink 008 - Disclosure - Note 2 - Summary of Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 009 - Disclosure - Note 3 - Fair Value of Financial Instruments link:calculationLink link:definitionLink link:presentationLink 010 - Disclosure - Note 4 - Balance Sheet Components link:calculationLink link:definitionLink link:presentationLink 011 - Disclosure - Note 5 - Goodwill link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note 7 - Research Grants and Agreements link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note 8 - Controlled Launch link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note 9 - Revenue link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Note 10 - Segment Reporting link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note 11 - Income Taxes link:calculationLink link:definitionLink link:presentationLink 018 - Disclosure - Note 12 - Related Party Transactions link:calculationLink link:definitionLink link:presentationLink 019 - Disclosure - Note 13 - Commitments and Contingencies link:calculationLink link:definitionLink link:presentationLink 020 - Disclosure - Note 14 - Restructuring Charges link:calculationLink link:definitionLink link:presentationLink 021 - Disclosure - Note 15 - Employee Benefit Plans link:calculationLink link:definitionLink link:presentationLink 022 - Disclosure - Note 16 - Supplementary Financial Information link:calculationLink link:definitionLink link:presentationLink 023 - Disclosure - Note 17 - Subsequent Events link:calculationLink link:definitionLink link:presentationLink 995470 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 995471 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Tables) link:calculationLink link:definitionLink link:presentationLink 995472 - Disclosure - Note 3 - Fair Value of Financial Instruments (Tables) link:calculationLink link:definitionLink link:presentationLink 995473 - Disclosure - Note 4 - Balance Sheet Components (Tables) link:calculationLink link:definitionLink link:presentationLink 995474 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation (Tables) link:calculationLink link:definitionLink link:presentationLink 995475 - Disclosure - Note 10 - Segment Reporting (Tables) link:calculationLink link:definitionLink link:presentationLink 995476 - Disclosure - Note 11 - Income Taxes (Tables) link:calculationLink link:definitionLink link:presentationLink 995477 - Disclosure - Note 13 - Commitments and Contingencies (Tables) link:calculationLink link:definitionLink link:presentationLink 995478 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995479 - Disclosure - Note 2 - Summary of Significant Accounting Policies - Warrant Accrual Activity (Details) link:calculationLink link:definitionLink link:presentationLink 995480 - Disclosure - Note 2 - Summary of Significant Accounting Policies - Antidilutive Securities (Details) link:calculationLink link:definitionLink link:presentationLink 995481 - Disclosure - Note 3 - Fair Value of Financial Instruments (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995482 - Disclosure - Note 3 - Investments and Fair Value of Financial Instruments - Financial Assets Measured on a Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 995483 - Disclosure - Note 4 - Balance Sheet Components (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995484 - Disclosure - Note 4 - Balance Sheet Components - Property and Equipment, Net (Details) link:calculationLink link:definitionLink link:presentationLink 995485 - Disclosure - Note 4 - Balance Sheet Components - Intangible Assets, Net (Details) link:calculationLink link:definitionLink link:presentationLink 995486 - Disclosure - Note 4 - Balance Sheet Components - Schedule of Amortization of Intangible Assets (Details) link:calculationLink link:definitionLink link:presentationLink 995487 - Disclosure - Note 4 - Balance Sheet Components - Accrued Expenses (Details) link:calculationLink link:definitionLink link:presentationLink 995488 - Disclosure - Note 5 - Goodwill (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995489 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995490 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Summary of Warrants Activity (Details) link:calculationLink link:definitionLink link:presentationLink 995491 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Summary of Stock Option Activity (Details) link:calculationLink link:definitionLink link:presentationLink 995492 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Summary of Time-based Option Activity (Details) link:calculationLink link:definitionLink link:presentationLink 995493 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Summary of Performance Option Activity (Details) link:calculationLink link:definitionLink link:presentationLink 995494 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Summary of Market-based Option Activity (Details) link:calculationLink link:definitionLink link:presentationLink 995495 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Option Assumptions (Details) link:calculationLink link:definitionLink link:presentationLink 995496 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - ESPP Assumptions (Details) link:calculationLink link:definitionLink link:presentationLink 995497 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Stock-based Compensation Expense by Recorded Location (Details) link:calculationLink link:definitionLink link:presentationLink 995498 - Disclosure - Note 6 - Stockholders' Equity and Stock-based Compensation - Stock-based Compensation Expense by Type (Details) link:calculationLink link:definitionLink link:presentationLink 995499 - Disclosure - Note 7 - Research Grants and Agreements (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995500 - Disclosure - Note 8 - Controlled Launch (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995501 - Disclosure - Note 9 - Revenue (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995502 - Disclosure - Note 10 - Segment Reporting (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995503 - Disclosure - Note 10 - Segment Reporting - Revenue by Product (Details) link:calculationLink link:definitionLink link:presentationLink 995504 - Disclosure - Note 10 - Segment Reporting - Revenue by Geography (Details) link:calculationLink link:definitionLink link:presentationLink 995505 - Disclosure - Note 11 - Income Taxes (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995506 - Disclosure - Note 11 - Income Taxes - Income (Loss) Before Income Taxes (Details) link:calculationLink link:definitionLink link:presentationLink 995507 - Disclosure - Note 11 - Income Taxes - Components of Provision for Income Taxes (Details) link:calculationLink link:definitionLink link:presentationLink 995508 - Disclosure - Note 11 - Income Taxes - Reconciliation of Provision for Income Taxes (Details) link:calculationLink link:definitionLink link:presentationLink 995509 - Disclosure - Note 11 - Income Taxes - Deferred Tax Asset (Liability) (Details) link:calculationLink link:definitionLink link:presentationLink 995510 - Disclosure - Note 11 - Income Taxes - Reconciliation of Unrecognized Tax Benefit (Details) link:calculationLink link:definitionLink link:presentationLink 995511 - Disclosure - Note 12 - Related Party Transactions (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995512 - Disclosure - Note 13 - Commitments and Contingencies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995513 - Disclosure - Note 13 - Commitments and Contingencies - Information Related to Right-of-use Assets and Lease Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 995514 - Disclosure - Note 14 - Restructuring Charges (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995515 - Disclosure - Note 15 - Employee Benefit Plans (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995516 - Disclosure - Note 17 - Subsequent Events (Details Textual) link:calculationLink link:definitionLink link:presentationLink