Management Team

  • Darrin R. Uecker

    Chief Executive Officer, President & Director
    Darrin R. Uecker has been our Chief Executive Officer and President and a Director since September 2015. Mr. Uecker has over 20 years of experience in the medical device field and is a named inventor on over 60 patents. Prior to Pulse Biosciences Mr. Uecker was the President and Chief Operating Officer of Progyny, Inc., Menlo Park, California, a company that developed EevaTM, the world’s first automated time-lapse system for embryo selection during in-vitro fertilization. Prior to that Mr. Uecker was the Chief Executive Officer and President and a Director of Gynesonics, Inc., Redwood City, California, a company that developed a novel medical device for the treatment of symptomatic uterine fibroids using ultrasound guided radiofrequency ablation. Mr. Uecker has served in a variety of executive level roles at CyperHeart, Inc., Conceptus, Inc., RITA Medical Systems, Inc., and Computer Motion, Inc. Mr. Uecker attended the University of California at Santa Barbara where he received a B.S. and M.S. in electrical and computer engineering.
    • Brian B. Dow

      Senior Vice President and Chief Financial Officer
      Brian B. Dow has been our Chief Financial Officer, Senior Vice President, Treasurer and Secretary since November 2015. Prior to joining Pulse Biosciences, Mr. Dow served as the Chief Financial Officer of Progyny, Inc. Prior to that, Mr. Dow was the Vice President and Principal Accounting Officer of Pacific Biosciences of California (NASDAQ: PACB), a leading provider of next generation genetic sequencing instruments. Mr. Dow held a series of financial officer positions with Northstar Neuroscience, Inc. (NASDAQ: NSTR), a development stage medical device company, most recently serving as the Chief Financial Officer. Prior to these roles, Mr. Dow had 14 years of progressively-increasing responsibilities in financial management of publicly-traded companies and in public accounting as a manager with Ernst and Young. Mr. Dow is recognized as a licensed Certified Public Accountant in the State of Washington and holds a B.S. in Management from the Georgia Institute of Technology.
      • Richard Nuccitelli, Ph.D.

        Chief Science Officer
        Richard Nuccitelli, Ph.D. has been our Chief Science Officer since November, 2014. He was a Professor of Molecular and Cellular Biology at UC Davis for 23 years. He left UC Davis in 2001 to form BioElectroMed and was half-time Professor at Old Dominion University from 2004-2007 where he worked with Karl Schoenbach and Stephen Beebe on the use of nanosecond pulsed electric fields. He was elected Fellow of the American Association for the Advancement of Science in 1995 and Fellow in the American Institute for Medical and Biological Engineering in 2015. He has 134 publications and 7 patents. Dr. Nuccitelli has both an M.S. degree in Physics and a Ph.D. in Biological Sciences from Purdue University.
        • David Danitz

          Vice President of Engineering
          David Danitz joined Pulse Biosciences in November 2015 as VP of Engineering. Mr. Danitz has over 20 years of medical device development experience and is the named inventor on over 45 US patents. Prior to Pulse Biosciences he held the position of Vice President, R&D - Custom Products at Earlens, where he led the development of a light-driven transducer that directly engaged the ear drum to generate sound. Before that, Mr. Danitz held the position of Vice President R&D for Gynesonics, where he led the development of the world’s first intrauterine ultrasound system with integrated RF ablation for an incisionless treatment of uterine fibroids. Mr. Danitz also served at Novare Surgical as Vice President of R&D where for 10 years his team brought medical devices to the market in the areas of cardiac, vascular, general, urologic and gynecologic surgery. Mr. Danitz has received several Medical Design Excellence Award’s. Mr. Danitz earned a BSME degree with high honors from the University of California at Santa Barbara, and a SMME degree from the Massachusetts Institute of Technology.
          • Ed Ebbers

            Vice President and General Manager of Dermatology
            Ed Ebbers joined Pulse Biosciences in August 2016 as Vice President and General Manager of the Dermatology franchise. Mr. Ebbers brings more than 35 years of senior leadership and general management experience with major dermatology, pharmaceutical and device brands including Zeltiq Aesthetics, Thermage, and Penederm Dermatologics. In these roles, he led worldwide product development, marketing and sales. At Pulse Biosciences, he manages the development of the dermatology franchise for the Company’s Nano-Pulse Stimulation technology. Mr. Ebbers holds a BBA from the University of Wisconsin, Eau Claire, and a MBA from the University of Minnesota, Carlson School of Management.
            • Holly Hartman

              Vice President, Business Development and Corporate Strategy
              Holly Hartman, Ph.D., J.D. joined Pulse Biosciences in August 2016 as Vice President, Business Development and Corporate Strategy. Dr. Hartman brings to Pulse Biosciences more than 15 years in scientific and financial roles in the life sciences industry. Prior to joining Pulse, Dr. Hartman served as Director, Business Development / External R&D / Strategy & Corporate Development at Amgen, where she helped to identify and evaluate strategic opportunities and partnerships for multiple therapeutic areas including oncology. Dr. Hartman has also held various positions in investment banking working on life sciences transactions. Dr. Hartman earned her Ph.D. in comparative pathology with an emphasis in immunopathology, J.D. and B.A. in zoology all from the University of California, Davis.
              • Jeff Kmetz

                Chief Business Officer
                Jeff Kmetz joined Pulse Biosciences in April 2018 as Chief Business Officer. Mr. Kmetz has more than 20 years of commercial and business development experience in the pharma/biotech industry. Mr. Kmetz offers a seasoned history of successfully launching, developing and optimizing the value of oncology assets. Most recently, Mr. Kmetz served as Head of Commercial Development at Pharmacyclics LLC where he was the commercial lead responsible for bringing IMBRUVICA to market for CLL. Prior to joining Pulse Biosciences, Mr. Kmetz held various positions with expertise spanning across sales, sales training, marketing, global commercial development, business development, and vendor management. He held the Director US Hematology Marketing position at Alexion Pharmaceuticals, Hematology Franchise Lead at Bayer Healthcare, and various oncology sales and marketing roles at Berlex Laboratories. Mr. Kmetz holds a Bachelor of Science degree in biology from Virginia Tech.
                • William Knape

                  Vice President, Regulatory, Clinical and Quality Affairs
                  William Knape joined Pulse Biosciences in May 2018 as Vice President, Regulatory, Clinical, and Quality Affairs. Mr. Knape is an expert in regulatory affairs, clinical and quality assurance specializing in FDA and CE submissions with over 25 years working directly with the FDA in the life sciences industry, for both Rx and OTC products. His experience includes multiple regulatory submissions of 510(k)s, PMAs, IDEs, Pre-IDEs and Q-Sub meetings and international registration filings for a wide variety of innovative and novel medical device and IVD companies. Mr. Knape has managed numerous worldwide multicenter, clinical studies from first-in-man to Phase IV clinical programs. Prior to joining Pulse, Mr. Knape served in senior roles as Senior Director and Vice-President, where he helped develop key financial opportunities with strategic partners in multiple therapeutic areas including dermatology, oncology, aesthetics, diabetes, regenerative medicine, neurology, cardiology, and gastroenterology. Mr. Knape earned his B.Sc. in Psychology and B.Sc. in Medical Technology with an emphasis in bioengineering from the University of Wyoming and serves on the College of Health Sciences Advisory Board.
                  • Edison Manuel

                    Vice President of Operations
                    Edison Manuel joined Pulse Biosciences in April 2017 as VP of Operations. Mr. Manuel has over 30 years of experience and held several senior level positions with the last 22 years focused on medical devices ranging from robotics, RF ablation systems, motion hand-held laparoscopic instruments and time-lapse imaging system. Mr. Manuel brings extensive experience in operations from start-up manufacturing into full commercial release, program management, factory integration and consolidation, strategic outsourcing and supply chain management. Prior to joining Pulse, he held similar positions at Progyny, Stellartech Research Corp and Novare Surgical Systems. Mr. Manuel also held senior level positions RITA Medical Systems and Computer Motion, Inc. Mr. Manuel earned a B.S. degree in Management and Industrial Engineering at Mapua Institute of Technology, Manila, Philippines.